Previous studies have shown that genetic variants of the CLOCK gene have been associated with a
risk of obesity. The aim of the study was to investigate the relationship of CLOCK SNPs o
hypertension and coronary artery disease in Russian population. We genotyped 1139 individuals of
Russian ethnicity including healthy subjects, patients with hypertension and patients with coronary
artery disease. In addition, we studied effect of SNPs on the structure of the CLOCK mRNA using
computational models. Blood pressure, total cholesterol (TC), triglycerides (TG), high-and low-density
lipoprotein levels (mg/dl), glucose (mg/dl) and body mass index (BMI, kg/m 2 ) were analyzed. There
was no association between polymorphism in the BMAL1 gene with diseases given. Computational
mRNA structure analysis has revealed changes in promoter and G2121A sites. Genetic variants of the CLOCK gene rs1801260, rs34789226, rs4865010 were positively associated with essential hypertension
and coronary artery disease in the sample of Russian population.